The first season of The Cleveland Show, an American Animated television series created by Seth MacFarlane, began airing on September 27, 2009, and ended after 21 episodes on May 23, 2010. Production of the 22 episode season began in May 2008 and was expected to begin broadcast in January 2009 but was later pushed back to September 2009. The DVD was released as a "Complete Season" featuring all of the aired episodes. It was released in the Region 1 on September 28, 2010, and was released in the Region 2 on October 11, 2010.

Season 2 of The Cleveland Show, an American animated television series created by Seth MacFarlane, began airing on September 26, 2010 and ended after 22 episodes on May 15, 2011. Fox ordered a second production series of 22 episodes in October 2009. This season included the return of Kanye West for an additional episode after he aired in the first season episode Brotherly Love. The article has The Cleveland Show co-creator Rich Appel stating he hopes there is even more to come and then goes on to say "He could not have been more collaborative or easier to work with. We're excited, because his character has become a recurring character in our universe… He'll become our Sideshow Bob!". The DVD was released as a "Complete Season" featuring all of the aired episodes, in Region 1 on September 27, 2011 and was released in Region 2 territories on January 30, 2012

The Cleveland Show's third season debuted on the Fox network on September 25, 2011, and concluded on May 20, 2012. On June 10, 2010, it was announced that the series had been renewed for a third season. According to co-creator Mike Henry, musical guests on season three were to originally include Kanye West, will.i.am, Nicki Minaj, Bruno Mars, Chris Brown, Darren Criss, Questlove, and Fergie. With the exception of Fergie and Darren Criss, all musical guests were included on Season 4. The hurricane-themed crossover episode with Family Guy and American Dad! aired on October 2, 2011. It was originally going to air in the second season but was postponed due to the April 25–28, 2011 tornado outbreak in the Southern United States.

The Cleveland Show's fourth and final season debuted on the Fox network on October 7, 2012, and concluded on May 19, 2013. On May 9, 2011, Fox announced that the series had been renewed for a fourth season. There will also be a tribute to the movie, Menace II Society. According to co-creator Mike Henry, celebrity guests on season four will include George Clinton, Nick Offerman, Dale Earnhardt, Jr., Shorty Rossi, Kasey Kahne and Tony Stewart. Originally to be included in Season 3, musical guests Kanye West, will.i.am, Questlove, Nicki Minaj and Bruno Mars were included in this season. On May 13, 2013, Fox announced that they would not be renewing The Cleveland Show for another season, making this one the final season. The series ended with the episode "Wheel! Of! Family!" on May 19, 2013. In August 2013, series creator Seth MacFarlane announced that Cleveland would be moving back to Quahog along with the Tubbs family to rejoin the Family Guy cast.